Salbutamol increases SMN mRNA and protein levels in spinal muscular atrophy cells.

نویسندگان

  • C Angelozzi
  • F Borgo
  • F D Tiziano
  • A Martella
  • G Neri
  • C Brahe
چکیده

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder caused by homozygous absence of the survival motor neuron gene (SMN1). All patients have at least one, usually two to four copies of the related SMN2 gene which, however, produce insufficient levels of functional SMN protein due to the exclusion of exon 7 in the majority of SMN2 transcripts. Here, we show that salbutamol, a beta2-adrenoceptor agonist, determines a rapid and significant increase in SMN2-full length mRNA and SMN protein in SMA fibroblasts, predominantly by promoting exon 7 inclusion in SMN2 transcripts. These data, together with previous clinical findings, provide a strong rationale to investigate further the clinical efficacy of salbutamol in SMA patients.

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عنوان ژورنال:
  • Journal of medical genetics

دوره 45 1  شماره 

صفحات  -

تاریخ انتشار 2008